
Activate Dual Wield in a profile where it's been unlocked, then quit and restart a new game. You will be able to play Dual Wield mode in the new profile.
Kill 50+ mutants with your Wii remote held sideways in one level to get an odd bonus of $1337.
Unlock one-player dual wield mode (two remotes but one lifebar) by completing Director's Cut. This mode will be available in both Story and Director's Cut modes.
Complete Story mode to unlock extra mutants in Story mode (Director's Cut already uses extra mutants).
All the achievements in the game are listed in the Extra Contents menu (the extra videos, music, images, and 3D models). Simply perform the task required to unlock the item.
Tailor you high scores to rack in the bonus for "beating the high score". If you cannot top your high score in a stage any more, you will not earn money for buying guns in the shop.
To get a consistent Goregasm combo, purchase and upgrade the autoshotgun to the maximum. All you need is one hit on most zombies to kill them, giving you one shot, one kill capability.
Complete the Director's Cut to unlock the minigun in the gun shop for Story and Director's Cut modes.
Complete Story Mode to unlock the Handcannon.
Complete Story Mode to unlock Director's Cut Mode.