
Beat Sandman in Title Defense and you'll unlock Mac's Last Stand. In this mode, you'll take on a different, random fighter (including Donkey Kong!) in consecutive rounds. If you lose three times, you're out.
Win ten rounds (not necessarily in a row) in Mac's Last Stand to unlock Champion Mode. This mode is a one-hit knockdown mode for Mac, so watch out! Be sure to hit the Home/Reset button when your knees hit the mat so the game won't save your losses!
Beat Contender Mode to see the credits (or view them under Options) and ward of boredom with a hidden minigame. You can use your cursor to correct misspellings in the developer credits, and remove the names of the fighters. Click on a name when it's spelled incorrectly and it will turn green and correct itself, giving you a point.
When your loss count reaches 100, you will unlock the Headgear option in your Career Options, which enables you to toggle the damage-reducing accessory before each fight. If you need to rack up some losses, try taking on Mr. Dream a few dozen times without fighting back!
To unlock a characters full range of audio clips, simply complete the three challenges for that fighter in Exhibition Mode. There are two sets of audio for each fighter (Normal and Title defense).
On the main menu (after you have chosen a profile), there are five different ways to interact with Mac.
Note: These only work while Mac's standing still, he won't react if you try to touch him while he's moving.
Punch-Out!! features a surprising finale for its Title Defense Mode. You can fight Donkey Kong ("The King of Swing!" "The Leader of the DK Krew!" "Jumpman's Bane!") in this mode, and, if you beat him in Last Stand, you'll unlock him in Exhibition Mode.
On Little Mac's 3rd and final knock down for a TKO, start pressing 1 and 2 and sometimes Little Mac will get angry and continue the fight with a little health left.
Want to go for a quick TKO in the next round? Work the opponent's energy bar to nearly zero and let the current round's timer expire.
On the next round, they usually start with the life you last left them with. Throw them down, and you should have most of the next round to KO them two more times for an easier TKO.
If you are about to lose a fight in Career Mode, hit + and choose "Restart". This will help you learn the opponents moves and weaknesses without having to practice or eat a loss (and ruin your "perfect" record).
While an opponent is knocked down, quickly press 1 and 2 repeatedly (or swing the Wii-mote in motion mode). Mac will pump himself up and regain some energy until the opponent gets up!
Additions by spectrum856
If you press the "-" button during the dialogue between rounds, Doc will chomp on a Remedy Bar, causing Mac to regain a bit of energy (you can only do this once per opponent).
Complete the Minor, Major and World Circuits to unlock Title Defense Mode. In Title Defense, you are challenged by all of the fighters you've already fought but with new patterns and strategies.